If you are just getting into programming, or VB.NET programming, this is a great book to pick up.This book starts with the absolute basics in programming and builds on it. It hits all of the fundamentals of programming, such as variables, their scope, if..then...else statements, loops, arrays, variable comparisons, etc.
This book doesn't get too advanced, though I did wish it would have touched on object oriented programming a little bit more. The earlier a beginner gets into OOP the better.
If you have programming experience, or experience with VB in general, pass this book up. You probably won't get so much (or anything) out of this book and there are better books to go to. As the title says, this is a beginner's guide.